doi: 10.1126/science.168.3937.1370.
Intracranial self-stimulation and wakefulness: effect of manipulating ambient brain catecholamines
- PMID: 4315436
- DOI: 10.1126/science.168.3937.1370
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Intracranial self-stimulation and wakefulness: effect of manipulating ambient brain catecholamines
Science.
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Abstract
Rats were given disulfiram, an inhibitor of norepinephrine biosynthesis, to see if norepinephrine is a transmitter for motivation in electrical stimulation of the brain. Animals given the drug paused in bar pressing, appearing asleep or sedated; if replaced on the bar, they always resumed pressing at normal rates. The decrease in bar pressing may result from a direct or indirect effect of the drug on wakefulness rather than on reward.
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