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. 1970 Jun 12;168(3937):1370-2.
doi: 10.1126/science.168.3937.1370.

Intracranial self-stimulation and wakefulness: effect of manipulating ambient brain catecholamines

S K Roll

Intracranial self-stimulation and wakefulness: effect of manipulating ambient brain catecholamines

S K Roll. Science. .

Abstract

Rats were given disulfiram, an inhibitor of norepinephrine biosynthesis, to see if norepinephrine is a transmitter for motivation in electrical stimulation of the brain. Animals given the drug paused in bar pressing, appearing asleep or sedated; if replaced on the bar, they always resumed pressing at normal rates. The decrease in bar pressing may result from a direct or indirect effect of the drug on wakefulness rather than on reward.

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