Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1970 May;39(1):87-98.
doi: 10.1111/j.1476-5381.1970.tb09558.x.

Localization of kininogenase in the rat kidney

K Nustad

Localization of kininogenase in the rat kidney

K Nustad. Br J Pharmacol. 1970 May.

Abstract

1. The rat kidney kininogenase (KGA) activity was located mainly in the kidney cortex.2. Differential centrifugation of kidney cortex homogenate revealed that the microsomal fraction contained more KGA activity per unit of protein than the other subcellular fractions.3. Subfractionation of the microsomal fraction showed that the KGA activity was recovered in a subfraction also containing high specific activity of both alkaline phosphate and glucose-6-phosphatase. It is suggested that the KGA activity is localized in the plasma membrane and/or endoplasmic reticulum membranes of kidney cortical cells.4. Hydrolysis of N-alpha-benzoyl-L-arginine ethyl ester at pH 8.5 paralleled the KGA activity.

PubMed Disclaimer

References

    1. Arch Int Pharmacodyn Ther. 1961 May 1;131:257-61 - PubMed
    1. Hoppe Seylers Z Physiol Chem. 1968 Jan;349(1):107-8 - PubMed
    1. Biochem J. 1956 Aug;63(4):606-8 - PubMed
    1. J Histochem Cytochem. 1955 Jul;3(4):246-70 - PubMed
    1. Biochem J. 1959 Dec;73:623-8 - PubMed

LinkOut - more resources