Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1979;8(Suppl 2):163S-166S.

A double-blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension

J J McNeil, W J Louis
Clinical Trial

A double-blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension

J J McNeil et al. Br J Clin Pharmacol. 1979.

Abstract

1 This study was designed to compare in a double-blind randomized crossover trial, atenolol, labetalol, metoprolol and pindolol. Considerable differences in dose (atenolol 138 +/- 13 mg daily; labetalol 308 +/- 34 mg daily; metoprolol 234 +/- 22 mg daily; and pindolol 24 +/-2 mg daily were required to produce similar antihypertensive effects. 3 The overall incidence of side-effects was similar with atenolol, metoprolol and pindolol but was slightly less with labetalol. Sleep disturbances and abnormal dreaming patterns were most frequent with pindolol. 4 There was a significantly greater fall in pulse rate during atenolol and metoprolol treatment periods.

PubMed Disclaimer

References

    1. Br Med J. 1964 Sep 19;2(5411):725-7 - PubMed
    1. Am J Med. 1976 May 31;60(6):872-6 - PubMed
    1. Br Med J. 1976 Jul 3;2(6026):7-9 - PubMed
    1. Med J Aust. 1972 Aug 5;2(6):309-12 - PubMed
    1. Postgrad Med J. 1971 Mar;47:Suppl:75-7 - PubMed

LinkOut - more resources