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. 1970 Mar;24(1):164-7.
doi: 10.1038/bjc.1970.19.

Induction of carcinomas in the nasal cavity of rats by dioxane

C Hoch-Ligeti, M F Argus, J C Arcos
Free PMC article

Induction of carcinomas in the nasal cavity of rats by dioxane

C Hoch-Ligeti et al. Br J Cancer. 1970 Mar.
Free PMC article

Abstract

Six out of 120 rats fed dioxane in drinking water at levels of 0.75, 1.0, 1.4 or 1.8% developed carcinomas in the nasal cavity. Spontaneous tumors at this tissue localization have not been reported to occur in laboratory animals. The carcinomas were pre-eminently of epidermoid type with few adenocarcinomatous areas and epithelial papillomas. Four rats with carcinoma of the nasal cavity had hepatocellular carcinoma in addition.

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