The actions of 5-hydroxytryptamine and histamine on the isolated ileum of the tree shrew (Tupaia glis)
- PMID: 43173
- PMCID: PMC2043660
- DOI: 10.1111/j.1476-5381.1979.tb10845.x
The actions of 5-hydroxytryptamine and histamine on the isolated ileum of the tree shrew (Tupaia glis)
Abstract
1. Contractions to 5-hydroxytryptamine (5-HT) and histamine of longitudinal muscle from the isolated ileum of the tree shrew (Tupaia), guinea-pig and rat were investigated by constructing dose-response curves and studying the effects of various antagonists. 2 In the Tupaia and rat ileum the contraction to 5-HT was reduced by methysergide but not affected by tetrodotoxin (TTX), morphine, hexamethonium (C6) or atropine. The response of guinea-pig ileum to 5-HT was not significantly inhibited by methysergide or C6, but was blocked by TTX, morphine and atropine. 3 Histamine-induced contraction of Tupaia and guinea-pig ileum was antagonized by diphenhydramine but not by TTX, morphine, C6 or atropine. Histamine was almost without effect on the rat ileum.
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