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. 1970 Feb;5(2):221-5.
doi: 10.1128/JVI.5.2.221-225.1970.

Host-range restrictions of murine leukemia viruses in mouse embryo cell cultures

J W Hartley, W P Rowe, R J Huebner

Host-range restrictions of murine leukemia viruses in mouse embryo cell cultures

J W Hartley et al. J Virol. 1970 Feb.

Abstract

Murine leukemia virus strains fall into three categories with respect to their ability to propagate in cells of National Institutes of Health (NIH) Swiss and BALB/c mouse embryos. Cultures of NIH cells are 100- to 1,000-fold more sensitive to "N-tropic" strains than BALB/c cell cultures, but are 30- to 100-fold less sensitive to "B-tropic" strains. Some virus strains (dually tropic or "NB-tropic") propagate equally well in both cells. M-MSV pseudotypes show the host-range characteristics of the virus supplying the envelope, both in vitro and in vivo. The host-range characteristics appear to be genetically determined and could not be explained by host-induced modification or virus mixtures. There was no correlation between host range and Gross-AKR or FMR serotype.

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