doi: 10.1126/science.169.3948.883.
Prostaglandin receptor site: evidence for an essential role in the action of luteinizing hormone
- PMID: 4317401
- DOI: 10.1126/science.169.3948.883
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Prostaglandin receptor site: evidence for an essential role in the action of luteinizing hormone
Science.
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Abstract
A dose-response relation was established between prostaglandins and formation of adenosine 3',5'-monophosphate in the mouse ovary. The prostaglandin antagonist, 7-oxa-13-prostynoic acid, blocked the stimulatory effect of prostaglandin E(1), prostaglandin E(2), and luteinizing hormone on adenosine 3',5'-monophosphate formation in a competitive manner. Kinetic studies made it possible to suggest that there is a single luteinizing-hormone-related prostaglandin receptor in mouse ovaries, and that activation of this prostaglandin receptor is an essential requirement in the action of luteinizing hormone to stimulate adenosine 3',5'-monophosphate formation and steroidogenesis.
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