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. 1979;5(3):136-42.
doi: 10.1159/000117675.

Effect of clozapine on apomorphine-induced growth hormone secretion and serum prolactin concentrations in schizophrenia

N P Nair, S Lal, P Cervantes, R Yassa, H Guyda

Effect of clozapine on apomorphine-induced growth hormone secretion and serum prolactin concentrations in schizophrenia

N P Nair et al. Neuropsychobiology. 1979.

Abstract

Clozapine had no effect on basal serum growth hormone concentrations in 10 schizophrenic patients but significantly inhibited the apomorphine-induced growth hormone increase that occurred in 7 subjects. Clozapine caused a slight (17%) but significant elevation in basal serum prolactin levels. These data suggest that in man clozapine, like other neuroleptics, blocks dopamine receptors, at least in the hypothalamic-pituitary axis.

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