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. 1970 Jul;20(1):23-5.
doi: 10.1128/am.20.1.23-25.1970.

Microbial transformation of 19-hydroxypregnanes

K Singh, D J Marshall, C Vézina

Microbial transformation of 19-hydroxypregnanes

K Singh et al. Appl Microbiol. 1970 Jul.

Abstract

Nocardia species aromatized 19-hydroxyprogesterone, 3beta, 19-dihydroxy-pregn-5-en-20-one 3-acetate and pregn-5-ene-3beta, 19, 20beta-triol 3-acetate, without cleavage of the side chain, into 3-hydroxy-19-norpregna-1,3,5 (10)-trien-20-one. Septomyxa affinis aromatized the ring A and cleaved the side chain of 19-hydroxyprogesterone to yield estrone. With 19-hydroxypregna-4, 7-diene-3, 20-dione as substrate, the transformation was more complex and many products were formed.

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References

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