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. 1970 Sep;67(1):193-9.
doi: 10.1073/pnas.67.1.193.

Antigenic study of unfertilized mouse eggs: cross reactivity with SV40-induced antigens

W Baranska, P Koldovsky, H Koprowski

Antigenic study of unfertilized mouse eggs: cross reactivity with SV40-induced antigens

W Baranska et al. Proc Natl Acad Sci U S A. 1970 Sep.

Abstract

Serum obtained from guinea pigs immunized with unfertilized C57BL/6 mouse eggs was found to be cytotoxic in the presence of complement for eggs obtained from syngeneic and allogeneic mice. The anti-egg serum was not cytotoxic for rat eggs, lymph node cells, methylcholanthrene-induced tumor cells, or 3T3 cells obtained either from syngeneic or allogeneic mice. The anti-egg serum was, however, cytotoxic for SV40-transformed 3T3 cells and C57BL/6 cells. After absorption with SV40-transformed cells, anti-egg serum lost its cytotoxicity for mouse eggs.

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