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. 1970 Sep;67(1):345-50.
doi: 10.1073/pnas.67.1.345.

Conversion of glycogen phosphorylase b to a by non-activated phosphorylase b kinase: an in vitro model of the mechanism of increase in phosphorylase a activity with muscle contraction

C Villar-Palasi, S H Wei

Conversion of glycogen phosphorylase b to a by non-activated phosphorylase b kinase: an in vitro model of the mechanism of increase in phosphorylase a activity with muscle contraction

C Villar-Palasi et al. Proc Natl Acad Sci U S A. 1970 Sep.

Abstract

Phosphorylase b kinase activity, as present in resting muscle in the non-activated form, appears to be ample to account for the fast appearance of phosphorylase a observed with muscle contraction. The kinase activity is repressed by free ATP and stimulated by free Mg(2+). Phosphorylase b kinase activity increases greatly when the Mg(2+):ATP ration exceeds 1. It is proposed that the breakdown of ATP that occurs during muscle contraction may represent the triggering factor for the observed in vivo conversion of phosphorylase b into a.

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References

    1. J Biol Chem. 1968 May 10;243(9):2200-8 - PubMed
    1. Biochim Biophys Acta. 1968 Jul 9;159(3):479-89 - PubMed
    1. J Biol Chem. 1968 Jul 10;243(13):3763-5 - PubMed
    1. Biochem Biophys Res Commun. 1968 Aug 21;32(4):704-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1968 Nov;61(3):1079-86 - PubMed

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