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. 1970 Nov 6;170(3958):633-5.
doi: 10.1126/science.170.3958.633.

Radioreceptor assay of adrenocorticotropic hormone: new approach to assay of polypeptide hormones in plasma

R J Lefkowitz, J Roth, I Pastan

Radioreceptor assay of adrenocorticotropic hormone: new approach to assay of polypeptide hormones in plasma

R J Lefkowitz et al. Science. .

Abstract

Biologically active iodine-125-labeled adrenocorticotropic hormone (ACTH) binds specifically to ACTH receptors extracted from adrenals. Unlabeled ACTH at 1 picogram per milliliter significantly displaces labeled ACTH from these receptors. This system, which appears to be applicable to all polypeptide hormones, provides a rapid and sensitive method for measurements of biologically active ACTH in dilute whole plasma.

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