Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1970 Aug;39(4):789-97.
doi: 10.1111/j.1476-5381.1970.tb09905.x.

Hyposensitivity to drugs induced by morphine and some related substances in the cat

E Contreras, F Huidobro

Hyposensitivity to drugs induced by morphine and some related substances in the cat

E Contreras et al. Br J Pharmacol. 1970 Aug.

Abstract

1. Hyposensitivity to noradrenaline occurred concomitantly with morphine tachyphylaxis in the absence of any obvious depressant effect on the heart or peripheral circulation.2. The actions of adrenaline, noradrenaline and angiotensin and, occasionally, other drugs were tested before and after repeated injections of morphine or one of ten related substances in various preparations of the spinal cat.3. Tachyphylaxis in response to morphine could be related to a simultaneous decrease in the tissue responses to adrenaline, noradrenaline and angiotensin but such a parallelism has not been shown for the substances related to morphine.

PubMed Disclaimer

References

    1. J Neurochem. 1968 Jan;15(1):17-23 - PubMed
    1. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1964 May 25;248:231-46 - PubMed
    1. Br J Pharmacol Chemother. 1957 Mar;12(1):115-8 - PubMed
    1. J Pharmacol Exp Ther. 1967 Jul;157(1):149-58 - PubMed
    1. Br J Pharmacol Chemother. 1957 Mar;12(1):119-27 - PubMed

LinkOut - more resources