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. 1970 Nov;67(3):1624-30.
doi: 10.1073/pnas.67.3.1624.

A specific competitive inhibitor of angiotensin II

G R Marshall, W Vine, P Needlemann

A specific competitive inhibitor of angiotensin II

G R Marshall et al. Proc Natl Acad Sci U S A. 1970 Nov.

Abstract

A peptide analog, [4-phenylalanine, 8-tyrosine]-angiotensin II, was prepared by solid phase peptide synthesis and its structure confirmed. The compound was found to be a potent inhibitor of angiotensin II in vitro (isolated rat uterus strips) and in vivo (rat blood pressure). The analog was found to be highly specific and did not inhibit the action of a number of other peptides and spasmogenic compounds.

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References

    1. Nature. 1965 May 8;206(984):619-20 - PubMed
    1. Helv Chim Acta. 1965 Sep 20;48(6):1407-14 - PubMed
    1. Biochemistry. 1966 Feb;5(2):657-65 - PubMed
    1. Nature. 1966 Sep 10;211(5054):1193-4 - PubMed
    1. J Am Chem Soc. 1967 Jan 4;89(1):181-2 - PubMed

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