Biosynthesis of presqualene pyrophosphate by liver microsomes
- PMID: 4322765
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Biosynthesis of presqualene pyrophosphate by liver microsomes
J Lipid Res.
1970 Sep.
Free article
Abstract
Microsomes from rat liver have been shown to synthesize a squalene precursor from farnesyl pyrophosphate. This intermediate is identical with presqualene pyrophosphate, a 30-carbon cyclopropane containing pyrophosphate ester that had previously been isolated from yeast. The squalene precursor was found to be tightly, but not covalently, bound to microsomes.
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