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. 1971 Apr;68(4):803-4.
doi: 10.1073/pnas.68.4.803.

Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine

M F Holick, H K Schnoes, H F DeLuca

Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine

M F Holick et al. Proc Natl Acad Sci U S A. 1971 Apr.

Abstract

A biologically active vitamin D(3) metabolite ("peak V metabolite") more polar than 25-hydroxycholecalciferol has been isolated from chicken intestines in pure form as a mono(trimethylsilyl)ether derivative. The molecule has been identified as 1,25-dihydroxycholecalciferol by means of mass spectrometry, ultraviolet absorption spectrophotometry, and specific chemical reactions.

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