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. 1971 Apr 23;172(3981):382-3.
doi: 10.1126/science.172.3981.382.

Immunoglobulin production by human lymphocytoid lines and clones: absence of genic exclusion

A D Bloom, K W Choi, B J Lamb

Immunoglobulin production by human lymphocytoid lines and clones: absence of genic exclusion

A D Bloom et al. Science. .

Abstract

Immunoglobulin production was studied in established lines of normal human lymphocytes. Three lines which produced both immunoglobulin G and immunoglobulin M were cloned. Among the 25 immunoglobulin-producing clones, 23 produced both classes of immunoglobulins. These findings suggest that the phenomenon of genic exclusion does not hold for immunoglobulin production in lymphocytoid cells in culture.

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