doi: 10.1126/science.172.3987.995.
Batrachotoxin: chemistry and pharmacology
- PMID: 4324825
- DOI: 10.1126/science.172.3987.995
Item in Clipboard
Batrachotoxin: chemistry and pharmacology
Science.
.
Abstract
Batrachotoxin has been shown to be a pyrrolecarboxylic ester of a novel steroidal base with unique and selective actions on a variety of electrogenic membranes. The effects of batrachotoxin in neuromuscular preparations both pre- and postsynaptically, in nerve axons, in superior cervical ganglion, in heart Purkinje fibers, and in brain slices appear to be due to the selective and irreversible increase in permeability of membranes to sodium ions. The subsequent effects of this increase in Na(+) permeability evoked by batrachotoxin-such as membrane depolarization, enhanced spontaneous transmitter release, muscle contracture, and enhanced formation of cyclic AMP in brain slices-may be blocked reversibly by tetrodotoxin.
Similar articles
-
The pharmacology of batrachotoxin. I. Effects on the contractile mechanism and on neuromuscular transmission of mammalian skeletal muscle.J Pharmacol Exp Ther. 1971 Mar;176(3):497-510. J Pharmacol Exp Ther. 1971. PMID: 4329451 No abstract available.
-
The pharmacology of batrachotoxin. II. Effect on electrical properties of the mammalian nerve and skeletal muscle membranes.J Pharmacol Exp Ther. 1971 Mar;176(3):511-28. J Pharmacol Exp Ther. 1971. PMID: 4329452 No abstract available.
-
The pharmacology of batrachotoxin. IV. Interaction with tetrodotoxin on innervated and chronically denervated rat skeletal muscle.J Pharmacol Exp Ther. 1972 Mar;180(3):683-97. J Pharmacol Exp Ther. 1972. PMID: 5012787 No abstract available.
-
Recent studies on the mode of action of scorpion neurotoxins. A review.Toxicon. 1969 Nov;7(3):217-21. doi: 10.1016/0041-0101(69)90008-7. Toxicon. 1969. PMID: 4311543 Review. No abstract available.
-
Divalent cations as charge carriers in excitable membranes.Prog Biophys Mol Biol. 1973;26:1-43. doi: 10.1016/0079-6107(73)90016-3. Prog Biophys Mol Biol. 1973. PMID: 4575321 Review. No abstract available.
Cited by
-
New directions in the chemistry of natural products: the organic chemist as a pathfinder for biochemistry and medicine.Experientia. 1971 Oct 15;27(10):1121-38. doi: 10.1007/BF02286882. Experientia. 1971. PMID: 4942649 Review. No abstract available.
-
The interaction of homologous series of alkanols with sodium channels in nerve membrane vesicles.J Membr Biol. 1988 Sep;104(2):139-46. doi: 10.1007/BF01870926. J Membr Biol. 1988. PMID: 2848131
-
Maitotoxin-activated single calcium channels in guinea-pig cardiac cells.Br J Pharmacol. 1987 Nov;92(3):665-71. doi: 10.1111/j.1476-5381.1987.tb11370.x. Br J Pharmacol. 1987. PMID: 2447990 Free PMC article.
-
Effects of yohimbine on squid axons.Biophys J. 1978 Nov;24(2):405-22. doi: 10.1016/S0006-3495(78)85391-0. Biophys J. 1978. PMID: 728522 Free PMC article.
-
Melyrid beetles (Choresine): a putative source for the batrachotoxin alkaloids found in poison-dart frogs and toxic passerine birds.Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15857-60. doi: 10.1073/pnas.0407197101. Epub 2004 Nov 1. Proc Natl Acad Sci U S A. 2004. PMID: 15520388 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
