doi: 10.1073/pnas.68.4.752.
RNA-dependent RNA polymerase activity associated with virions and subviral particles of myxoviruses
- PMID: 4325103
- PMCID: PMC389035
- DOI: 10.1073/pnas.68.4.752
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RNA-dependent RNA polymerase activity associated with virions and subviral particles of myxoviruses
Proc Natl Acad Sci U S A.
1971 Apr.
Abstract
In vitro RNA synthesis is catalyzed by an enzyme found in purified virions of each of nine influenza strains tested. The extent of [(3)H]UTP incorporation observed is strain dependent, with an obligate requirement for Mn(2+) ions and RNA template. At least 30% of purified product RNA shows resistance to degradation by ribonuclease A and T1 before and after annealing with exogenous RNA from influenza virions.
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