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. 1971 Jun 25;172(3990):1353-5.
doi: 10.1126/science.172.3990.1353.

Heterogeneity of murine leukemia virus in vitro DNA; detection of viral DNA in mammalian cells

L D Gelb, S A Aaronson, M A Martin

Heterogeneity of murine leukemia virus in vitro DNA; detection of viral DNA in mammalian cells

L D Gelb et al. Science. .

Abstract

Kinetic analysis of the reassociation of DNA synthesized in vitro by a murine leukemia virus DNA polymerase revealed two classes of double-stranded product representative of 25 and 100 percent of viral genetic information. The DNA product representing the smaller portion of the viral genome comprised 85 percent of the double-stranded DNA generated in vitro and was extensively duplicated in the genomes of both normal cells and cells containing RNA tumor virus.

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