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. 1971 May;42(1):153-4.
doi: 10.1111/j.1476-5381.1971.tb07095.x.

Prostaglandin E1 and noradrenaline at the neuromuscular junction

B L Ginsborg, G D Hirst

Prostaglandin E1 and noradrenaline at the neuromuscular junction

B L Ginsborg et al. Br J Pharmacol. 1971 May.

Abstract

The effects of prostaglandin E(1) (PGE(1)) on neuromuscular transmission in the frog nerve-sartorius muscle preparation were studied with intracellular recording techniques. PGE(1) was inactive in all concentrations examined; both spontaneous miniature end-plate potentials and evoked end-plate potentials were unchanged after preparations were bathed in up to 2.2x10(-5)M (8 mug/ml) PGE(1). PGE(1) did not prevent the increase in end-plate potential amplitude which frequently occurred on addition of noradrenaline to the bathing solution.

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