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. 1971 Jul 2;173(3991):51-4.
doi: 10.1126/science.173.3991.51.

1,25-dihydroxycholecalciferol: identification of the proposed active form of vitamin D3 in the intestine

A W Norman, J F Myrtle, R J Midgett, H G Nowicki, V Williams, G Popják

1,25-dihydroxycholecalciferol: identification of the proposed active form of vitamin D3 in the intestine

A W Norman et al. Science. .

Abstract

The major polar metabolite of cholecalciferol (vitamin D(3)) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C(27)H(44)0(3) and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produced in the kidney from 25-hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25-Dihydroxycholecalciferol (previously designated metabolite 4B in this (laboratory) probably represents the biologically active form of cholecalciferol in the intestine.

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