doi: 10.1126/science.432648.
Iron deficiency prevents liver toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin
- PMID: 432648
- DOI: 10.1126/science.432648
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Iron deficiency prevents liver toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin
Science.
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Abstract
The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatocellular damage and porphyria in C57B1/6J mice, among a wide range of toxic effects. We compared the effect of TCDD toxicity in iron-deficient mice with that in mice receiving a normal diet. Porphyria did not develop in the iron-deficient animals, and these animals were also protected from hepatocellular damage and certain other toxic effects of TCDD.
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