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. 1971 Jul;68(7):1441-3.
doi: 10.1073/pnas.68.7.1441.

Effect of rifampicin and two of its derivatives on cells infected with Moloney sarcoma virus

M Calvin, U R Joss, A J Hackett, R B Owens

Effect of rifampicin and two of its derivatives on cells infected with Moloney sarcoma virus

M Calvin et al. Proc Natl Acad Sci U S A. 1971 Jul.

Abstract

It is shown that rifampicin, and especially the related antibiotic 2',6'-dimethyl-N(4')-benzyl-N(4')- [desmethyl]rifampicin (DMB-rifampicin) can inhibit focus formation by Moloney sarcoma virus on BALB/3T3 tissue cultures. At 10 mug/ml DMB-rifampicin totally inhibits focus formation while reducing virus replication by at least a factor of fifty and cell proliferation by only a factor of three. These observations, taken together with those of others, suggest a role for an RNA-dependent DNA polymerase and the gene for its synthesis both in normal cell processes and in the transformation process.

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References

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