Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1970 Jul;56(1):33-45.
doi: 10.1085/jgp.56.1.33.

Desensitization of gamma aminobutyric acid (GABA) receptors in muscle fibers of the crab Cancer borealis

R Epstein, H Grundfest

Desensitization of gamma aminobutyric acid (GABA) receptors in muscle fibers of the crab Cancer borealis

R Epstein et al. J Gen Physiol. 1970 Jul.

Abstract

Carcinus muscle fibers respond to gamma-aminobutyric acid (GABA) with a conductance increase that subsides rather rapidly. In the larger fibers which have low input resistance the decrease may disappear within 2 min. The inhibition of the excitatory postsynaptic potentials (EPSP's) by GABA nevertheless persists as long as the drug is applied. The subsidence of the increased conductance indicates that the membrane of the inhibitory synapses has become desensitized to GABA. The persistence of inhibition of the EPSP's appears to be due to an action of the drug on the presynaptic terminals of the excitatory axons which reduces or blocks the secretory activity that releases the excitatory transmitter.

PubMed Disclaimer

References

    1. Adv Comp Physiol Biochem. 1966;2:1-116 - PubMed
    1. J Neurochem. 1959 Apr;4(1):19-30 - PubMed
    1. Am Zool. 1967 Aug;7(3):435-49 - PubMed
    1. J Physiol. 1965 Mar;177:225-38 - PubMed
    1. J Physiol. 1966 Mar;183(2):418-32 - PubMed

MeSH terms