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. 1971 Feb;7(2):227-32.
doi: 10.1128/JVI.7.2.227-232.1971.

Deoxyribonucleic acid polymerases of Rous sarcoma virus: kinetics of deoxyribonucleic acid synthesis and specificity of the products

A C Garapin, L Fanshier, J A Leong, J Jackson, W Levinson, J M Bishop

Deoxyribonucleic acid polymerases of Rous sarcoma virus: kinetics of deoxyribonucleic acid synthesis and specificity of the products

A C Garapin et al. J Virol. 1971 Feb.

Abstract

The deoxyribonucleic acid (DNA) polymerase(s) of Rous sarcoma virus synthesizes two principal products-single-stranded DNA in the form of a DNA:ribonucleic acid (RNA) hybrid and double-stranded DNA. All of the single-stranded product and 50% of the double-stranded product can be hybridized to 70S viral RNA. These results, in combination with data obtained by analysis of the kinetics of double-stranded DNA synthesis, indicate that the synthesis of double-stranded DNA is a sequel to the synthesis of single-stranded DNA and is dependent upon the latter for the provision of initial template.

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References

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    1. J Mol Biol. 1969 Dec 14;46(2):235-49 - PubMed
    1. Nature. 1970 Jun 27;226(5252):1209-11 - PubMed
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