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. 1971 Apr;7(4):473-7.
doi: 10.1128/JVI.7.4.473-477.1971.

Relationship between virus-induced cellular deoxyribonucleic acid synthesis and transformation by simian virus 40

T O Fox, A J Levine

Relationship between virus-induced cellular deoxyribonucleic acid synthesis and transformation by simian virus 40

T O Fox et al. J Virol. 1971 Apr.

Abstract

The fraction of cells in a confluent 3T3 cell monolayer induced by simian virus 40 infection to replicate deoxyribonucleic acid and divide corresponds to those cells which eventually become transformed. Virus-induced cells were partially separated from noninduced cells by sedimentation through Ficoll gradients. Three- to eightfold higher transformation frequencies were obtained with those cells that began to synthesize cellular deoxyribonucleic acid and divide shortly after simian virus 40 infection as compared to noninduced cells.

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