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. 1971 Apr;7(4):478-85.
doi: 10.1128/JVI.7.4.478-485.1971.

Defective interfering particles of poliovirus. I. Isolation and physical properties

C N Cole, D Smoler, E Wimmer, D Baltimore

Defective interfering particles of poliovirus. I. Isolation and physical properties

C N Cole et al. J Virol. 1971 Apr.

Abstract

A class of defective interfering (DI) poliovirus particles has been identified. The first was found as a contaminant of a viral stock; others have been isolated by serial passage at a high multiplicity of infection. The DI particles are less dense than standard virus and sediment more slowly. Their ribonucleic acid (RNA) sediments more slowly than standard RNA and has a higher electrophoretic mobility. Competition hybridization experiments with double-stranded viral RNA indicate that DI RNA is 80 to 90% of the length of standard RNA. The proteins of DI particles are indistinguishable from those of standard poliovirus.

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