Transplacental chemical carcinogenesis in man
- PMID: 4330461
Transplacental chemical carcinogenesis in man
Abstract
PIP: This editorial was prompted by the published association of maternal diethylstilbestrol (DES) ingestion during pregnancy and subsequent development of vaginal adenocarcinoma among female offspring, and explores various factors involved in transplacental chemical carcinogenesis in humans. Known prenatal determinants of carcinogenic transmission are 1) germ cells, 2) transplantation, and 3) ionizing radiation. Other chemicals besides DES which may be implicated in transplacental carcinogenesis are cytotoxic anticancer agents, such as therapy. The hypothesis of DES-associated maternal-fetal exchange was developed as a result of physician recognition of a cluster of cases with commonality; it is hoped that further epidemiological studies, more systemitized, will lead to hypotheses regarding the epidemiology of other in utero carcinogenesis.
Similar articles
-
[Transplacental carcinogenesis].Vestn Akad Med Nauk SSSR. 1977;(10):14-9. Vestn Akad Med Nauk SSSR. 1977. PMID: 411275 Review. Russian. No abstract available.
-
Vaginal and cervical cancers and other abnormalities associated with exposure in utero to diethylstilbestrol and related synthetic hormones.Cancer Res. 1977 Apr;37(4):1249-51. Cancer Res. 1977. PMID: 844051 No abstract available.
-
Transplacental carcinogenesis by stilbestrol.N Engl J Med. 1971 Aug 12;285(7):404-5. doi: 10.1056/NEJM197108122850711. N Engl J Med. 1971. PMID: 5556579
-
Vaginal and cervical cancers and other abnormalities associated with exposure in utero to diethylstilbestrol and related synthetic hormones.J Med Assoc State Ala. 1977 Mar;46(9):39-41. J Med Assoc State Ala. 1977. PMID: 845523 No abstract available.
-
The current status of the DES-exposed population.Obstet Gynecol Annu. 1981;10:267-78. Obstet Gynecol Annu. 1981. PMID: 7024873 Review.
Cited by
-
Carcinogenesis across the placenta.Br Med J. 1973 Aug 4;3(5874):250. Br Med J. 1973. PMID: 4723461 Free PMC article. No abstract available.
-
Carcinogenesis and aging--two related phenomena? A review.Am J Pathol. 1977 May;87(2):444-72. Am J Pathol. 1977. PMID: 322509 Free PMC article. Review. No abstract available.
-
Medulloblastoma in infancy associated with omphalocele, malrotation of the intestine, and extrophy of the bladder.Childs Nerv Syst. 1988 Apr;4(2):108-11. doi: 10.1007/BF00271391. Childs Nerv Syst. 1988. PMID: 3401871
-
The biological basis and clinical significance of hormonal imprinting, an epigenetic process.Clin Epigenetics. 2011 Aug;2(2):187-96. doi: 10.1007/s13148-011-0024-8. Epub 2011 Mar 1. Clin Epigenetics. 2011. PMID: 22704336 Free PMC article.
-
Shifting paradigms in health services research ethics. Consent, privacy, and the challenges for IRBs.J Gen Intern Med. 2006 Mar;21(3):279-80. doi: 10.1111/j.1525-1497.2006.00391.x. J Gen Intern Med. 2006. PMID: 16637827 Free PMC article. No abstract available.