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. 1971 Nov;8(5):661-8.
doi: 10.1128/JVI.8.5.661-668.1971.

Regulation of protein synthesis in HeLa cells. 3. Inhibition during poliovirus infection

R Leibowitz, S Penman

Regulation of protein synthesis in HeLa cells. 3. Inhibition during poliovirus infection

R Leibowitz et al. J Virol. 1971 Nov.

Abstract

The mechanism of inhibition of host cell protein synthesis by poliovirus has been studied by examining the behavior of host polyribosomes and polyribosome-associated messenger ribonucleic acid (mRNA). Virus infection appears to result in a specific inhibition of the initiation of translation of host cell mRNA. The site of inhibition does not appear to be mRNA itself. Human cells respond to virus infection by producing a factor antagonistic to the virus inhibition which promotes the initiation of host mRNA translation. The production of the host factor is sensitive to actinomycin; however, the behavior of the host cell factor and that of host mRNA appear distinctly different.

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References

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