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. 1971 Feb 1;133(2):275-88.
doi: 10.1084/jem.133.2.275.

Isolation of a tumor factor responsible for angiogenesis

J Folkman, E Merler, C Abernathy, G Williams

Isolation of a tumor factor responsible for angiogenesis

J Folkman et al. J Exp Med. .

Abstract

Human and animal solid tumors elaborate a factor which is mitogenic to capillary endothelial cells. This factor has been called tumor-angiogenesis factor. The important components of TAF are RNA and protein. It is suggested that blockade of this factor (inhibition of angiogenesis) might arrest solid tumors at a tiny diameter of a few millimeters.

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