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. 1971 Oct;68(10):2391-5.
doi: 10.1073/pnas.68.10.2391.

Helper activity of human leukemic tissue extracts for leukemia virus expression in mice

R A Steeves, A Fjelde, E A Mirand

Helper activity of human leukemic tissue extracts for leukemia virus expression in mice

R A Steeves et al. Proc Natl Acad Sci U S A. 1971 Oct.

Abstract

Extracts of cultured human leukemic tissues increased the spleen focus-forming activity of Friend leukemia virus preparations in BALB/c and other partially resistant mice. Such mice carry the Fv-1(b) gene, which inhibits the expression of helper virus indigenous to the Friend virus complex, and allows co-infecting leukemia viruses of mice, cats, or chickens to substitute for the inhibited helper virus and increase the expression of the spleen focus-forming virus. The helper activity of extracts from human leukemic tissues shared several important properties with that associated with known leukemogenic viruses of animals.

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