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. 1972 Jan;9(1):110-5.
doi: 10.1128/JVI.9.1.110-115.1972.

Immunological relationships of reverse transcriptases from ribonucleic acid tumor viruses

Immunological relationships of reverse transcriptases from ribonucleic acid tumor viruses

W P Parks et al. J Virol. 1972 Jan.

Abstract

Antiserum to partially purified reverse transcriptase from the Schmidt-Ruppin strain of Rous sarcoma virus has been prepared and characterized. Antibody to the avian polymerase inhibited the reverse transcriptase activity of avian C-type viruses but had no effect on the polymerase activity from C-type viruses of other classes. The known mammalian C-type viral polymerases were significantly inhibited only by the antiserum to murine C-type viral polymerases; reverse transcriptases from four other mammalian viruses were immunologically distinct from both avian and mammalian C-type viral polymerases. Partially purified murine leukemia viral DNA polymerase activity was comparably reduced by specific antibody regardless of the template used for enzyme detection.

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