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. 1972 Mar;69(3):553-7.
doi: 10.1073/pnas.69.3.553.

Role of calcium and adenosine-3':5'-cyclic monophosphate in controlling fly salivary gland secretion

W T Prince, M J Berridge, H Rasmussen

Role of calcium and adenosine-3':5'-cyclic monophosphate in controlling fly salivary gland secretion

W T Prince et al. Proc Natl Acad Sci U S A. 1972 Mar.

Abstract

The action of 5-hydroxytryptamine (5-HT) on an insect salivary gland was associated with a rise in adenosine-3':5'-cyclic monophosphate (cAMP) concentration and an increase in calcium uptake. An increase in secretion induced either by 5-HT or exogenous cAMP required extracellular calcium. Both 5-HT and exogenous cAMP increased (45)Ca efflux from previously labeled glands, but only 5-HT caused an increase in calcium uptake. The transepithelial potential in this tissue became more negative after addition of 5-HT, but more positive after addition of cAMP. 5-HT and cAMP induced a more negative potential when calcium was removed from the medium. It was concluded that both calcium and cAMP serve as intracellular messengers when 5-HT acts upon fly salivary gland.

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