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. 1972 Jan;70(1):175-80.
doi: 10.1093/genetics/70.1.175.

Site of action of 3',5'-cyclic adenosine monophosphate in production of tryptophanase in Escherichia coli

L Immken, D Apirion

Site of action of 3',5'-cyclic adenosine monophosphate in production of tryptophanase in Escherichia coli

L Immken et al. Genetics. 1972 Jan.

Abstract

3',5' cyclic-AMP (cAMP) will stimulate the rate of tryptophanase synthesis in Escherichia coli cultures induced with tryptophan. Adding cAMP after the initiation of messenger RNA synthesis was blocked by rifampicin, did not stimulate tryptophanase synthesis. This indicates that cAMP acts at initiation of either transcription or translation and not at the level of chain elongation of either the messenger or the polypeptide chain.

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References

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    1. Biochem Biophys Res Commun. 1970 Jul 13;40(1):77-84 - PubMed
    1. Biochim Biophys Acta. 1961 Apr 29;49:77-88 - PubMed

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