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. 1972 Feb;47(251):62-5.
doi: 10.1136/adc.47.251.62.

Diagnosis of congenital adrenal hyperplasia by measurement of plasma 17-hydroxyprogesterone

N D Barnes, S M Atherden

Diagnosis of congenital adrenal hyperplasia by measurement of plasma 17-hydroxyprogesterone

N D Barnes et al. Arch Dis Child. 1972 Feb.

Abstract

Measurement of plasma 17-hydroxyprogesterone by a simple competitive protein-binding assay has proved of value in the diagnosis of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Children with untreated adrenal hyperplasia had high resting levels from as early as the 6th day of life, and children treated with suppressive doses of cortisone showed a rise after adrenal stimulation with tetracosactrin. The method also promises to enhance the ease and precision with which the condition can be managed.

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References

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