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. 1972 Apr;9(4):701-4.
doi: 10.1128/JVI.9.4.701-704.1972.

Comparison of murine sarcoma viruses in nonproducer and S + L - -transformed cells

S A Aaronson, R H Bassin, C Weaver

Comparison of murine sarcoma viruses in nonproducer and S + L - -transformed cells

S A Aaronson et al. J Virol. 1972 Apr.

Abstract

The biologic properties of murine sarcoma viruses in nonproducer and S(+)L(-) cells were compared. Each virus was found to be genetically stable through at least two cycles of rescue and transmission to new cells. There was no evidence for production of a defective murine leukemia virus by S(+)L(-) cells. The results are most consistent with the hypothesis that the sarcoma genome in S(+)L(-) cells contains information for replication functions which the virus in nonproducer cells either lacks or does not express.

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