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. 1972 Jun 16;176(4040):1247-8.
doi: 10.1126/science.176.4040.1247.

5,6-Trans-25-hydroxycholecalciferol: vitamin D analog effective on intestine of anephric rats

M F Holick, M Garabedian, H F DeLuca

5,6-Trans-25-hydroxycholecalciferol: vitamin D analog effective on intestine of anephric rats

M F Holick et al. Science. .

Abstract

A new compound, 5,6-trans-25-hydroxycholecalciferol, has been synthesized and tested for its biological activity. Like 1,25-dihydroxycholecalciferol, it stimulates intestinal calcium transport in anephric rats, whereas 25-hydroxycholecalciferol does not. But this analog has little if any activity in stimulating mobilization of calcium from the bone of anephric rats.

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