doi: 10.1126/science.176.4039.1146.
1,25-dihydroxycholecalciferol: metabolite of vitamin D3 active on bone in anephric rats
- PMID: 4338462
- DOI: 10.1126/science.176.4039.1146
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1,25-dihydroxycholecalciferol: metabolite of vitamin D3 active on bone in anephric rats
Science.
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Abstract
Nephrectomy prevents completely the bone calcium mobilization response to 25-hydroxycholecalciferol. In contrast it does not prevent this response to 1,25-dihydroxycholecalciferol. Because it is known that the kidney is the site of 1,25-dihydroxycholecalciferol formation, these results provide evidence that 1,25-dihydroxycholecalciferol or a further metabolite thereof and not 25-hydroxycholecalciferol is the metabolically active form of vitamin D(3) responsible for bone calcium mobilization.
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