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. 1972 Jun 9;176(4039):1146-7.
doi: 10.1126/science.176.4039.1146.

1,25-dihydroxycholecalciferol: metabolite of vitamin D3 active on bone in anephric rats

M F Holick, M Garabedian, H F DeLuca

1,25-dihydroxycholecalciferol: metabolite of vitamin D3 active on bone in anephric rats

M F Holick et al. Science. .

Abstract

Nephrectomy prevents completely the bone calcium mobilization response to 25-hydroxycholecalciferol. In contrast it does not prevent this response to 1,25-dihydroxycholecalciferol. Because it is known that the kidney is the site of 1,25-dihydroxycholecalciferol formation, these results provide evidence that 1,25-dihydroxycholecalciferol or a further metabolite thereof and not 25-hydroxycholecalciferol is the metabolically active form of vitamin D(3) responsible for bone calcium mobilization.

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