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. 1972 May;11(1):99-108.

Experimental chronic active hepatitis in rabbits following immunization with human liver proteins

K H Büschenfelde, F K Kössling, P A Miescher

Experimental chronic active hepatitis in rabbits following immunization with human liver proteins

K H Büschenfelde et al. Clin Exp Immunol. 1972 May.

Abstract

Two liver-specific antigens are known: a water soluble protein (LP-2) and a water insoluble macromolecular low density lipoprotein (LP-1).

In this paper the relative role of the two antigens in the development of experimental immune hepatitis has been investigated. Immunization of rabbits with a human preparation containing both antigens, led in all animals to lesions characteristic of an immune hepatitis. Immunization of the animals with a purified water soluble liver protein proved less efficient: only two out of six animals developed characteristic lesions which were less severe than those in the first group. It was deduced that although not a prerequisite, the liver-specific lipoprotein plays an important supportive role in the development of immune hepatitis.

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