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. 1971 Dec;43(4):757-63.
doi: 10.1111/j.1476-5381.1971.tb07211.x.

Lack of relationship between myocardial cyclic AMP concentrations and inotropic effects of sympathomimetic amines

B G Benfey

Lack of relationship between myocardial cyclic AMP concentrations and inotropic effects of sympathomimetic amines

B G Benfey. Br J Pharmacol. 1971 Dec.

Abstract

1. Sympathomimetic amines which increase the contractility of the isolated heart were tested for effects on cyclic AMP concentrations in rabbit heart slices and on adenyl cyclase activity in rabbit heart homogenate.2. Noradrenaline, as expected, stimulated adenyl cyclase activity and increased cyclic AMP concentrations, but dopamine and phenylephrine were ineffective.3. This result does not support the concept that cyclic AMP plays an essential role in the inotropic effect of sympathomimetic amines.

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