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. 1972 Sep;69(9):2542-6.
doi: 10.1073/pnas.69.9.2542.

Individual states in the cycle of muscle contraction

C G Dos Remedios, R G Yount, M F Morales

Individual states in the cycle of muscle contraction

C G Dos Remedios et al. Proc Natl Acad Sci U S A. 1972 Sep.

Abstract

By using appropriate analogs of ATP, isometrically-held glycerol-extracted psoas fibers from rabbits are forced successively into states corresponding to molecular species in the contractile cycle. In each state measurements are made of P[unk], a fluorescence polarization parameter thought to relate to attitude of S-1 moieties of the myosin molecules. Also, the value of P[unk] is measured during active tension development. It is suggested that this value is a time-average of the P[unk] as S-1 moieties move through the various states of the cycle. Proposals are made concerning the sequence of states in the cycle.

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References

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