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. 1972 Mar;127(1):113-8.
doi: 10.1042/bj1270113.

D-myoinositol 1:2-cyclic phosphate 2-phosphohydrolase

R M Dawson, N Clarke

D-myoinositol 1:2-cyclic phosphate 2-phosphohydrolase

R M Dawson et al. Biochem J. 1972 Mar.

Abstract

1. An enzyme in extracts of mammalian tissues catalyses the hydrolysis of d-myoinositol 1:2-cyclic phosphate (an intermediary in the enzymic degradation of phosphatidylinositol) to produce d-myoinositol 1-phosphate. 2. The enantiomorph of the substrate is not attacked. 3. The pH optimum is about 8.1-8.3 and the reaction is stimulated by Mg(2+) ions. 4. Extracts from rat kidney cortex and medulla are very rich sources of the enzyme; brain, testis and small intestine contain intermediary activities, and other tissues contain very small amounts.

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