Comparative Study
doi: 10.1128/iai.4.5.563-566.1971.
Comparison between the polymyxins and gentamicin in preventing endotoxin-induced intravascular coagulation and leukopenia
- PMID: 4343409
- PMCID: PMC416353
- DOI: 10.1128/iai.4.5.563-566.1971
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Comparative Study
Comparison between the polymyxins and gentamicin in preventing endotoxin-induced intravascular coagulation and leukopenia
Infect Immun.
1971 Nov.
Abstract
Three antimicrobial agents were evaluated as to their ability to neutralize the toxic effects of endotoxin in rabbits. These consisted of two cyclic polypeptides, polymyxin B sulfate and colymycin M (sodium colistimethate), and an aminoglycoside, gentamicin sulfate. Polymyxin B regularly prevented endotoxin-induced leukopenia, thrombocytopenia, and disseminated intravascular coagulation. Colymycin M had similar activity but was not as effective as polymyxin B. Gentamicin demonstrated no neutralizing ability in this study.
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