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. 1972 Oct;26(5):361-7.
doi: 10.1038/bjc.1972.47.

Biological effects of Corynebacterium parvum. 3. Amplification of resistance and impairment of active immunity to murine tumours

S E Smith, M T Scott
Free PMC article

Biological effects of Corynebacterium parvum. 3. Amplification of resistance and impairment of active immunity to murine tumours

S E Smith et al. Br J Cancer. 1972 Oct.
Free PMC article

Abstract

The effect of pre-treatment with Corynebacterium parvum on the growth in vivo of a range of experimental mouse tumours with differing characteristics has been investigated. Varying degrees of protection were observed which were generally greater with the more immunogenic tumours. Administration of C. parvum 7 days before immunization with irradiated tumour cells diminished the protective effect which could be obtained by immunization alone. The possible basis for these seemingly conflicting influences is considered.

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