Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1972 Nov;6(5):743-7.
doi: 10.1128/iai.6.5.743-747.1972.

Hyporeactivity of infection: potential limitation to therapeutic use of interferon-inducing agents

D A Stringfellow, L A Glasgow

Hyporeactivity of infection: potential limitation to therapeutic use of interferon-inducing agents

D A Stringfellow et al. Infect Immun. 1972 Nov.

Abstract

Interferon inducers are generally most effective as antiviral agents when used prophylactically. One possible explanation for this is that animals develop a state of hyporeactivity during the course of a virus infection. Such a progressive loss of capacity to produce interferon was observed with a representative group of interferon-inducing agents (polyinosinic-cytidylic acid, Tilorone hydrochloride, New-castle disease virus, or a strain of encephalomyocarditis virus) during the course of a model picornavirus infection in mice.

PubMed Disclaimer

References

    1. Nature. 1965 Oct 30;208(5009):456-8 - PubMed
    1. Proc Soc Exp Biol Med. 1966 Mar;121(3):819-24 - PubMed
    1. Proc Soc Exp Biol Med. 1967 Feb;124(2):347-53 - PubMed
    1. J Exp Med. 1968 May 1;127(5):1035-52 - PubMed
    1. Science. 1968 Nov 15;162(3855):811-3 - PubMed

LinkOut - more resources