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. 1973 Jan;70(1):245-9.
doi: 10.1073/pnas.70.1.245.

Mutagenic DNA polymerase in human leukemic cells

C F Springgate, L A Loeb

Mutagenic DNA polymerase in human leukemic cells

C F Springgate et al. Proc Natl Acad Sci U S A. 1973 Jan.

Abstract

Evidence is presented that DNA polymerases from human leukemic cells are mutagenic. Nucleic acid-free extracts of acute lymphoblastic leukemic cells polymerized about 10-times more dCTP using poly(dA-dT).poly(dA-dT) as a template than did extracts from normal lymphocytes. Mutagenic DNA polymerases could perhaps play an important role in tumor progression.

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References

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