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. 1979 Mar;54(3):190-3.
doi: 10.1136/adc.54.3.190.

Dosage schedule for intravenous aminophylline in apnoea of prematurity, based on pharmacokinetic studies

R A Jones, E Baillie

Dosage schedule for intravenous aminophylline in apnoea of prematurity, based on pharmacokinetic studies

R A Jones et al. Arch Dis Child. 1979 Mar.

Abstract

15 preterm infants were treated for recurrent apnoea with theophylline. 5 were given oral choline theophyllinate, but this was erratically absorbed. 14 were given IV aminophylline on 23 occasions. Apparent volume of distribution of theophylline in 12 infants was 0.71 +/- 0.18 1/kg (mean +/- SD). Plasma clearance rate measured in 11 infants at steady state was 18.6 +/- 4.8 ml/kg per hour. Calculations show that a loading dose of 6.2 mg/kg aminophylline intravenously and maintenance of 4.4 mg/kg per day would produce serum levels of between 6 and 12 mg/l in all but one of the infants studied, with no infant having toxic levels.

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References

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